High-power Femtosecond-THz Pulse Induces a Wound Response in Mouse Skin
Terahertz (THz) technology has emerged for biomedical applications such as scanning, molecular spectroscopy, and medical imaging. Although a thorough assessment to predict potential concerns has to precede before practical utilization of THz source, the biological effect of THz radiation is not yet fully understood with scant related investigations. We applied a femtosecond-terahertz (fs-THz) pulse to mouse skin to evaluate non-thermal effects of THz radiation. Repeated fs-THz radiation delayed the closure of mouse skin punch wounds due to up-regulation of TGF-b. These findings suggested that fs-THz radiation initiate a wound-like signal in skin with increased expression of TGF-b and activation of its downstream target genes, which perturbs the wound healing process in vivo.
<Kyu-Tae Kim, Jaehun Park, Sung jin Jo, Seonghoon Jung, Oh Sang Kwon, Gian Piero Gallerano, Woong-Yang Park and Gun-Sik Park, High-power femtosecond-terahertz pulse induces a wound response in mouse skin, Scientific reports, 2013, 3, 2296>